Effects of acupuncture on granulocyte apoptosis and expressions of apoptosis-associated genes in the ovary of perimenopausal rats / 中国针灸
Chinese Acupuncture & Moxibustion
;
(12): 357-361, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-351866
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of acupuncture for treatment of perimenopausal syndrome.</p><p><b>METHODS</b>The rats of perimenopausal syndrome were randomly divided into 3 groups, including an acupuncture group treated with acupuncture, a medication group with Gengnian'an, and a perimenopausal control group, with young rats used for a control group. Granulocyte apoptosis and expressions of Bcl-2 and Fas proteins in the ovary of the rat were detected.</p><p><b>RESULTS</b>Granulocyte apoptosis increased significantly (P < 0.01), expression of Bl-2 proteins decreased significantly (P < 0.01) and expression of Fas proteins increased significantly (P < 0.01) in the ovary of perimenopausal rats as compared with the young rats; after acupuncture treatment, granulocyte apoptosis decreased significantly (P < 0.05), expression of Bel-2 proteins increased significantly (P < 0.05) and expression of Fas proteins decreased significantly (P < 0.01); after treatment of Gengnian'an, granulocyte apoptosis did not significantly change (P > 0.05), expression of Bcl-2 prteins increased significantly (P < 0.05) and expression of Fas proteins decreased significantly (P < 0.01).</p><p><b>CONCLUSION</b>Acupuncture can inhibit granulocyte apoptosis, up-regulate expression of Bcl-2 proteins and down-regulate expression of Fas proteins in the ovary of the perimenopausal rat.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ovário
/
Patologia
/
Terapia por Acupuntura
/
Ratos Sprague-Dawley
/
Apoptose
/
Receptor fas
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Perimenopausa
/
Granulócitos
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Acupuncture & Moxibustion
Ano de publicação:
2007
Tipo de documento:
Artigo
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