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Effects of anti- CXCR4 monoclonal antibody on adhesiveness of human acute myelocytic leukemia cell line HL-60 and expression of Bcl-2, Fas proteins / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 436-440, 2004.
Artigo em Chinês | WPRIM | ID: wpr-352047
ABSTRACT
To study the importance of chemokine SDF-1 in surviving of acute myelocytic leukemia cells HL-60, the adhesion ability of HL-60 and expression of Bcl-2, Fas protein when SDF-1 activity was blocked by anti-CXCR4 monoclonal antibody (12G5) were compared with those detected before MAb incubation, in this experiment, HL-60 cell were cultured and co-cultured with normal marrow stromal cell. The adhesion rate was detected while the expression of Bcl-2 and Fas proteins were assayed by immunohistochemical technique when SDF-1 activity was inhibited. The results showed that cell adhesion rate of HL-60 decreased while the expression Bcl-2 decreased and Fas increased. It is concluded that inhibition of SDF-1 activity increases cell apoptosis and thus reduces life-span of leukemia cell at certain level.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Fisiologia / Adesão Celular / Química / Apoptose / Células HL-60 / Receptor fas / Proteínas Proto-Oncogênicas c-bcl-2 / Receptores CXCR4 / Quimiocinas CXC Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Fisiologia / Adesão Celular / Química / Apoptose / Células HL-60 / Receptor fas / Proteínas Proto-Oncogênicas c-bcl-2 / Receptores CXCR4 / Quimiocinas CXC Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2004 Tipo de documento: Artigo