Study of the preparation of silk fibroin gel and its morphology as drug release matrix in vitro and in vivo / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 794-811, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-352164
ABSTRACT
Silk fibroin (SF)/sodium alginate (SA) hydrogels can be used as drug injection materials. Homogenate was prepared by centrifugation of the pig myocardial extracellular matrix (PMM) and its modification of SF gel material. This paper observes and compares the different components SF, SF/SA, SF/SA/PMM to illustrate the SF/SA/PMM ternary material as a drug delivery composition material. This ternary material can shorten the gel time, and can make the gel form to be maintained better. Meanwhile, it makes the internal structure of the gel looser so that the hole wall becomes thinner and more conducive to the drug release. In addition, it has good biocompatibility proved by pathological analysis, and is able to enhance the mesenchymal stem cells growth activity, which has great significance in carrying out drug control release.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Suínos
/
Extratos de Tecidos
/
Materiais Biocompatíveis
/
Portadores de Fármacos
/
Química
/
Hidrogéis
/
Ácido Glucurônico
/
Preparações de Ação Retardada
/
Alginatos
/
Matriz Extracelular
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2013
Tipo de documento:
Artigo
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