The Effect of Intrav it real Injection of tPA and C3F8 Gas in Submacular Hemorrhage

ABSTRACT

This study was designed to evaluate the efficacy of intravitreal injection of tPA &C3F8 gas in submacular hemorrhage. Fourteen patients with sub-macular hemorrhage received an intravitreal injection of tPA &C3F8 gas and maintained face down position for 2 weeks. We investigated the feature of blood absorption, the correlation between underlying disease, hemorrhage size, duration and visual outcome. Underlying disease seemed to be a prognostic factor related to final visual acuity. Patients with choroidal rupture had better visual prognosis than those with age-related macular degeneration. The duration between the formation of submacular hemorrhage and treatment was correlated with final visual acuity, however, it was not sta-tisticallly significant. We have shown that submacular hemorrhage could be displaced by tPA and C3F8 gas injection in our most cases. In 7 of total 14 cases, visual acuity improved. The result suggests that this technique may be good for the initial treatment if done in appropriate timing in cases of submacular hemorrhage due to its simplicity and it can achieve relatively good results.