Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 236-240, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-352277
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the collagen constitution of hyperplastic scar (HS) in different ages and the change of relative factors.</p><p><b>METHODS</b>Thirty cases with HS were divided into two groups according to patients' age group 1 (1 - 19 years, A) and group 2 (20 - 50 years, B). The normal skin (NS) from corresponding age of volunteers was employed as control group. The changes in TGFbeta1, collagenase (MMP-1) and tissue inhibitor of metalloproteinase (TIMP-1beta) and the collagen ratio were observed by means of in situ hybridization technique and SABC (Strept-Avidin-Biotin complex) immunohistochemistry and image analysis.</p><p><b>RESULTS</b>The ratio of type I to type III collagen in A group was 6.48 in average and 3.76 in B group, but there was no evident difference in the ratio during the disease process in both groups. The expression of TGFbeta1 in A group was much higher than that in B group (P < 0.01). The TIMP-1 mRNA expression showed no difference among all age groups in HS patients, but it was much higher than that in NS group. The MMP-1 expression was evidently lower than TIMP-1 expression, and there was no difference in MMP-1 expression compared with NS group.</p><p><b>CONCLUSION</b>(1) The TGFbeta1 expression in HS patients was negatively correlated with age, and the increased expression of TGFbeta1 produced an increase ratio of type I to type III collagen. (2) High level expression of TIMP-1 led to the formation of HS by inhibiting MMP-1 expression, and the expression was not related to age.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Queimaduras
/
Fatores Etários
/
Cicatriz Hipertrófica
/
Inibidor Tecidual de Metaloproteinase-1
/
Metaloproteinase 1 da Matriz
/
Colágeno Tipo I
/
Colágeno Tipo III
/
Fator de Crescimento Transformador beta1
/
Metabolismo
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Burns
Ano de publicação:
2003
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS