Molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia / 中华烧伤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia.</p><p><b>METHODS</b>Differential expression of the genes in rat myocardium and skeletal muscles after severe hypoxia for 6 hours was determined by DNA chip containing 4096 mice genes.</p><p><b>RESULTS</b>There were high expressions of 125 genes in skeletal muscles and 111 genes in myocardial cells after 6 hours of severe hypoxia. Among them, high expression genes in myocardial cells included those encoding apoptosis activator Mtd, complement C3, vascular cell adhesion molecule-1, integrin beta subunit and lipopolysaccharide binding proteins (LBP).</p><p><b>CONCLUSION</b>Activation of apoptosis of myocardial cells and inflammatory mediators played important roles in myocardial cell injury after 6-hour severe hypoxia.</p>