Protective effect of amlodipine against contrast agent-induced renal injury in elderly patients with coronary heart disease / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1580-1583, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-352381
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the protective effect of amlodipine against contrast agent-induced renal injury in elderly patients with coronary heart disease.</p><p><b>METHODS</b>A total of 189 elderly patients (>60 years) with coronary heart disease undergoing coronary artery angiography were randomly assigned into amlodipine group and control group to receive amlodipine or placebo, respectively, before and after administration of the contrast agent. At 24 h, 48 h and 5 days after contrast agent administration, the parameters of renal function were measured including serum cystatin C, urea nitrogen, creatinine, creatinine clearance rate, urine β2-microglobulin, and urine N-acetyl-β-glucosaminidase.</p><p><b>RESULTS</b>In both groups, the contrast agents obviously affected the renal functions of the patients (P<0.05). At 24 h after contrast administration, the levels of serum cystatin C, urine β2-microglobulin and urine NAG were significantly lower in amlodipine group than in the control group, but the other functional parameters showed no significant difference. At 48 h after contrast administration, the glomerular and tubular functional parameters were all superior in amlodipine group (P<0.05). At 5 days, the two groups showed significant differences in such glomerular and tubular functional parameters as urea nitrogen, creatinine, creatinine clearance rate, urine β2-microglobulin, and urine NAG (P<0.05), but not in serum cystatin C level. The incidence of contrast agent-induced nephropathy was significantly lower in amlodipine group than in the control group (5/95 vs 10/94, P<0.05).</p><p><b>CONCLUSIONS</b>Amlodipine offers protection against radiographic contrast agent-induced renal injury in elderly patients with coronary heart disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Diagnóstico por Imagem
/
Angiografia Coronária
/
Anlodipino
/
Meios de Contraste
/
Doença das Coronárias
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Nefropatias
/
Testes de Função Renal
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo diagnóstico
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Artigo
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