Effects of marine collagen peptide on delaying the skin aging / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 235-238, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-352506
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of marine collagen peptides (MCPs) on the skin of aged mice induced by D-galactose.</p><p><b>METHODS</b>Subchronic toxicity study was conducted while D-galactose induced subacute aging model was established. D-galactose dose of 0.125 g/kg body weight was intraperitoneally injected daily for 90 days. Marine collagen peptide 0.225, 0.450, 1.350 g/kg body weight were administered by oral gavage. Superoxide dismutase (SOD), catalase (CAT) activity and malondialdehyde (MDA) content in blood serum were measured, along with cutaneous histopathology examination.</p><p><b>RESULTS</b>Epidermal thickness was significantly higher in MCPs treated group. Number and activity of fibroblast in MCPs treated dermis was increased prominently. The activity of SOD in 0.225, 0.450, 1.350 g/kgbw MCPs treated groups were 455.52 +/- 11.39, 460.15 +/- 18.09, 468.59 +/- 27.25 U/ml respectively, each of which was significantly higher than that in model control group; the activity of serum CAT in 0.225, 1.350 g/kgbw MCPs treated groups (21.33 +/- 4.82, 21.69 +/- 1.68 U/ml) were obviously increased compared with that in model control group (17.14 +/- 2.81 U/ml); MDA level in 0.450, 1.350 g/kgbw MCPs treated groups were 5.67 +/- 0.93, 5.76 +/- 1.02 nmol/ml respectively, each of which was significantly lower than that in model control group (7.63 +/- 1.37 nmol/ml).</p><p><b>CONCLUSIONS</b>The results showed that MCPs might play a protective role on skin aging by improving the activity of antioxidant.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peptídeos
/
Farmacologia
/
Superóxido Dismutase
/
Sangue
/
Envelhecimento da Pele
/
Colágeno
/
Ratos Sprague-Dawley
/
Malondialdeído
/
Biologia Marinha
/
Antioxidantes
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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