Baroreceptor reflex in heart failure / 生理学报
Acta Physiologica Sinica
;
(6): 269-281, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-352781
ABSTRACT
Congestive heart failure is a syndrome that is usually initiated by a reduction in pump function of the heart, i.e. a decrease in cardiac output. Initially, a reduction in cardiac output leads to unloading of baroreceptor reflex that, in turn, increases heart rate through vago-sympathetic mechanisms and total peripheral resistance via an increase in sympathetic outflow to vascular beds. In this review we are thinking on how baroreceptor reflex plays a role in the abnormal control of the circulation in heart failure. This review and our recent studies suggest that (1) baroreceptor reflex is blunted in heart failure; (2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex; (3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Sistema Nervoso Simpático
/
Resistência Vascular
/
Angiotensina II
/
Débito Cardíaco
/
Exercício Físico
/
Células Quimiorreceptoras
/
Espécies Reativas de Oxigênio
/
Barorreflexo
/
Insuficiência Cardíaca
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo
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