TAR DNA binding protein-43 and fused in sarcoma/translocated in liposarcoma protein in two neurodegenerative diseases / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 286-292, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-352913
ABSTRACT
TAR DNA binding protein-43(TDP-43) and fused in sarcoma/translocated in liposarcoma protein (FUS/TLS) have been found to be associated with two neurodegenerative diseases - amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in TDP-43 and FUS/TLS lead to abnormal protein expressions, which result in altered RNA processing. The pathological changes of TDP-43 and FUS/TLS-associated ALS and FTD are similar. Although the interactions between ALS and FTD remain unknown, it is speculated that TDP-43 and FUS/TLS-associated neurodegenerative diseases may share similar pathogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Processamento Pós-Transcricional do RNA
/
Proteína FUS de Ligação a RNA
/
Proteínas de Ligação a DNA
/
Demência Frontotemporal
/
Genética
/
Esclerose Lateral Amiotrófica
/
Metabolismo
/
Mutação
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS