Time to disappearance of thyroglobulin antibodies and influencing factors in patients with papillary thyroid carcinoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 258-261, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-352917
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the time to disappearance of thyroglobulin antibodies (TgAb) and its influencing factors in papillary thyroid carcinoma (PTC) patients with positive TgAb after radioiodine ((131)I) ablation.</p><p><b>METHODS</b>We retrospectively analyzed the clinical data of 64 PTC patients who had undergone a total thyroidectomy and subsequent (131)I therapy. Patients were divided into two groups according to the presence of concurrent Hashimoto thyroiditis (HD). TgAb1 (TgAb levels determined before (131)I therapy) were above the normal thresholds in all patients. The method of survival analysis (including Life tables and Cox Regression analysis) was used to assess the time to disappearance of TgAb and its influencing factors.</p><p><b>RESULTS</b>The median time to disappearance of positive TgAb (9.0 months vs. 10.4 months, P=0.923) showed no significant difference between these two groups. Cox Regression analysis showed that, among the potential influencing factors including TgAb [partial regression coefficient (B)=-0.004, P=0.001], age(B=-0.018, P=0.362), sex (B=0.644, P=0.320) and HD (B=0.341, P=0.372), only TgAb1 was correlated with the TgAb negative conversion time.</p><p><b>CONCLUSIONS</b>TgAb1 has remarked influence on the time to disappearance of positive TgAb in PTC patients. Patients with a higher TgAb need longer time to achieve negative conversion.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Radioterapia
/
Autoanticorpos
/
Sangue
/
Neoplasias da Glândula Tireoide
/
Carcinoma
/
Carcinoma Papilar
/
Estudos Retrospectivos
/
Seguimentos
/
Usos Terapêuticos
/
Alergia e Imunologia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2012
Tipo de documento:
Artigo
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