Role of beta-catenin in the pathogenesis of mesial temporal lobe epilepsy / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 659-662, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-352968
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of beta-catenin in the pathogenesis of mesial temporal lobe epilepsy.</p><p><b>METHODS</b>Kainic acid-induced rat models of medial temporal lobe epilepsy was established. The expression of beta-catenin in the normal mice and the model mice were detected using Western blot analysis. The expression of beta-catenin at human hippocampus was detected using immunohistochemical analysis and immunofluorescence and compared between patients with non-hippocampal sclerosis temporal lobe epilepsy and those with hippocampal sclerosis epilepsy.</p><p><b>RESULTS</b>The pathologies of model mice were similar with those in mice with hippocampal sclerosis temporal lobe epilepsy, demonstrating that the mice model was successfully established. Western blot analysis showed no significant difference of beta-catenin expression between normal mice and model mice. As shown by immunohistochemical analysis and immunofluorescence, beta-catenin expression in human hippocampus was also not significantly different between patients with temporal lobe epilepsy without hippocampal sclerosis and those with hippocampal sclerosis.</p><p><b>CONCLUSION</b>Beta-catenin may not be involved in the development of hippocampal sclerosis of mesial temporal lobe epilepsy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Modelos Animais de Doenças
/
Epilepsia do Lobo Temporal
/
Beta Catenina
/
Metabolismo
/
Camundongos Endogâmicos C57BL
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2011
Tipo de documento:
Artigo
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