Screening for phenylketonuria in 726,998 neonates in Zhejiang Province / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 185-187, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-353221
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the results of screening for neonatal phenylketonuria (PKU) in Zhejiang Province.</p><p><b>METHODS</b>The screening for neonatal PKU was conducted among 726,998 newborns in Zhejiang Province. Heel prick blood specimens were collected around 72 h after birth with 6 intakes of high protein milk and the specimens were dried on S and S903 filter papers. Phenylalanine (Phe) levels were determined quantitatively with Perkin Elmer Neonatal Fluorometric PKU kits.</p><p><b>RESULTS</b>Among 726,998 newborns, elevated blood Phe levels were found in 152 infants. They were all recalled for serum amino acid analysis and 32 were confirmed to have PKU with 19 males and 13 females. The earliest time of confirmation was 16 d and latest was 105 d with the median of 32 d.</p><p><b>CONCLUSION</b>The data shows that the detection rate of screening for neonatal phenylketonuria in Zhejiang Province was 1/22,718.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenilalanina
/
Fenilcetonúrias
/
Sangue
/
China
/
Epidemiologia
/
Incidência
/
Triagem Neonatal
Tipo de estudo:
Estudo diagnóstico
/
Estudo de incidência
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2005
Tipo de documento:
Artigo
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