Modulating drug loading and release profile of beta-cyclodextrin polymers by means of cross-linked degree / 药学学报
Acta Pharmaceutica Sinica
; (12): 221-226, 2011.
Article
em En
| WPRIM
| ID: wpr-353319
Biblioteca responsável:
WPRO
ABSTRACT
The purpose of the present study is to use beta-cyclodextrin polymers (beta-CDP) with different cross-linked degree (CLD) to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of beta-CDP on its drug loading and release behaviors. A series of beta-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and 13C NMR spectrum. The beta-CDP was systemically characterized for the relation between the CLD of beta-CDP and the drug loading and release as well. The results of FT-IR and 13C NMR showed that similar peak-shaped vibration of beta-CDP and beta-CD implies that the polymer keeps the original characteristic structure of beta-CD. The CLD of the beta-CDP played a critical role in the drug loading and release, increasing the CLD resulted in reduction of drug loading, but increase in drug release.
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Índice:
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Assunto principal:
Polímeros
/
Solubilidade
/
Isótopos de Carbono
/
Portadores de Fármacos
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Preparações Farmacêuticas
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Espectroscopia de Ressonância Magnética
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Química
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Ibuprofeno
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Sistemas de Liberação de Medicamentos
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Espectroscopia de Infravermelho com Transformada de Fourier
Idioma:
En
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Article