Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo / 药学学报
Acta Pharmaceutica Sinica
;
(12): 70-74, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-353328
ABSTRACT
To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Inibidores da Agregação Plaquetária
/
Estrutura Molecular
/
Distribuição Aleatória
/
Química
/
Agregação Plaquetária
/
Ratos Wistar
/
Tienopiridinas
/
Antagonistas do Receptor Purinérgico P2Y
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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