G3BP: a promising target for cancer therapy / 药学学报
Acta Pharmaceutica Sinica
;
(12): 945-951, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-353400
ABSTRACT
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation, differentiation, apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology, G3BP may provide a new target for cancer therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fragmentos de Peptídeos
/
Fosforilação
/
Dados de Sequência Molecular
/
Transdução de Sinais
/
Proteínas de Transporte
/
Sistemas de Liberação de Medicamentos
/
DNA Helicases
/
Domínios de Homologia de src
/
RNA Helicases
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo
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