In vitro absorption mechanism of strychnine and the transport interaction with liquiritin in Caco-2 cell monolayer model / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1160-1164, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-353407
ABSTRACT
To study the effect of liquiritin (Liq) on the transport of strychnine (Str) in Caco-2 cell monolayer model, the transport parameters of Str, such as apparent permeability coefficient (P app (B-->A) and P app (A-->B)) and cumulative transport amount (TRcum), were determined and comparatively analyzed when Str was used solely and co-used with Liq. The effect of drug concentrations, conveying times, P-glycoprotein (P-gp) inhibitor verapamil and conveying liquor pH values on the transport of Str were also investigated. The results indicated that the absorption of Str in Caco-2 cell monolayer model was well and the passive transference was the main intestinal absorption mechanism of Str in the Caco-2 monolayer model, along with the excretion action mediated by P-gp. Liq enhanced the absorption of Str. Meanwhile, conveying liquor pH value had significant influence on the excretion transport of Str.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Permeabilidade
/
Farmacologia
/
Plantas Medicinais
/
Estricnina
/
Transporte Biológico
/
Farmacocinética
/
Verapamil
/
Química
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Células CACO-2
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS