Your browser doesn't support javascript.
loading
Intervention of cetirizine on monocyte chemoattractant protein-1 in cutaneous inflammation / 药学学报
Acta Pharmaceutica Sinica ; (12): 414-417, 2005.
Artigo em Chinês | WPRIM | ID: wpr-353445
ABSTRACT
<p><b>AIM</b>To study the intervention of cetirizine on monocyte chemoattractant protein-1 (MCP-1) in different cutaneous inflammation models.</p><p><b>METHODS</b>Histamine and IFN-gamma stimulated dermal fibroblast cells and HaCaT cells to mimic cutaneous inflammation. Expression of MCP-1 was assessed by means of RT-PCR and ELISA.</p><p><b>RESULTS</b>Compared with the control group of dermal fibroblast (DF) cells and HaCaT cells, MCP-1 mRNA was significantly upregulated by histamine (10 micromol x L(-1)) and IFN-gamma (20 ng x mL(-1)). The protein secretions of MCP-1 were increased 3.5 fold and 8.4 fold in DF cells, respectively. The similar tendency was observed in HaCaT cells. The enhancing effects of histamine and IFN-gamma on MCP-1 protein production were significantly inhibited by cetirizine (1 and 10 micromol x L(-1)) in DF and HaCaT cells.</p><p><b>CONCLUSION</b>Cetirizine may exert the anti-inflammatory effect of skin via inhibiting MCP-1 expression.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / RNA Mensageiro / Histamina / Queratinócitos / Linhagem Celular / Células Cultivadas / Interferon gama / Cetirizina / Quimiocina CCL2 / Derme Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2005 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / RNA Mensageiro / Histamina / Queratinócitos / Linhagem Celular / Células Cultivadas / Interferon gama / Cetirizina / Quimiocina CCL2 / Derme Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2005 Tipo de documento: Artigo