Effects of ferulic acid on E-selectin expression in activated endothelial cell and leukocyte-endothelial cell adhesion / 药学学报
Acta Pharmaceutica Sinica
;
(12): 410-413, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-353446
ABSTRACT
<p><b>AIM</b>To study the effects of ferulic acid (FA) on E-selectin expression in human umbilical vein endothelial cells (HUVECs) activated by lipopolysaccharide and leukocyte-endothelial cell adhesion.</p><p><b>METHODS</b>The effects of FA on E-selectin and E-selectin mRNA expression were determined by flow cytometry and reverse transcription polymerase chain reaction. The effect of FA on HL60-HUVEC adhesion was evaluated with the method of staining the cells by Rose Bengal.</p><p><b>RESULTS</b>The expression of E-selectin and E-selectin mRNA were down regulated by FA (0.62 and 0.41 mmol x L(-1), respectively). HL60 cells adhered to activated HUVECs were also reduced by FA (0.62 and 0.41 mmol x L(-1), respectively).</p><p><b>CONCLUSION</b>FA can inhibit the expression of E-selectin and E-selectin mRNA and HL60-HUVEC adhesion. This may contribute to its protective effect against ischemia-reperfusion injury.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Veias Umbilicais
/
RNA Mensageiro
/
Adesão Celular
/
Células Cultivadas
/
Células HL-60
/
Selectina E
/
Ácidos Cumáricos
/
Biologia Celular
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Artigo
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