Effect of imidapril on the effective refractory period and sodium current of ventricular noninfarction zone in healed myocardial infarction / 药学学报
Acta Pharmaceutica Sinica
;
(12): 654-658, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-353455
ABSTRACT
<p><b>AIM</b>To investigate the effects of imidapril (IMI) on effective refractory period (ERP) and sodium current (I(Na)) of myocytes in ventricular noninfarction zone of healed myocardial infarction (HMI) in rabbit models.</p><p><b>METHODS</b>Rabbits with left coronary artery ligation were prepared and IMI (0.625 mg x kg(-1) x d(-1), 8 weeks) was orally administered. The ERP and sodium current were recorded.</p><p><b>RESULTS</b>The ERP in HMI heart was prolonged. The ERP in IMI group was lower significantly than that of HMI group. The I(Na) density of myocyte in HMI ventricle decreased obviously. V 1/2 of steady state inactivation of I(Na) shifted to hyperpolarization, and time constant (tau) of recovery from inactivation in HMI ventricular myocyte was longer than that of sham ventricular myocyte. I(Na) density in IMI group increased markedly as compared with that of HMI group.</p><p><b>CONCLUSION</b>IMI was shown to reverse the abnormal prolongation of ERP in rabbit heart with the HMI and increase I(Na) density. It may be the mechanism of IMI preventing against antiarrhythmia in healed myocardical infarction.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Período Refratário Eletrofisiológico
/
Inibidores da Enzima Conversora de Angiotensina
/
Canais de Cálcio
/
Biologia Celular
/
Miócitos Cardíacos
/
Imidazolidinas
/
Ventrículos do Coração
/
Metabolismo
/
Infarto do Miocárdio
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Artigo
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