Preparation of 8-chloro-adenosine long circulation liposomes and its pharmacokinetics in rats / 药学学报

ABSTRACT

<p><b>AIM</b>To prepare 8-chloro-adenosine (8-Cl-A) long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo.</p><p><b>METHODS</b>To prepare 8-Cl-A long circulation liposomes of nanometer size by improved multiple emulsion. The entrapped efficiency, size and size distribution of 8-Cl-A long circulation liposomes were determined, and its pharmacokinetics in rats was evaluated.</p><p><b>RESULTS</b>The entrapped efficiency of 8-Cl-A long circulation liposomes was 62.70% and mean diameter of the liposomes was 79.9 nm. The pharmacokinetics studies indicated that 8-Cl-A long circulation liposomes showed higher drug concentration and larger AUC values than that of 8-Cl-A after iv to rats.</p><p><b>CONCLUSION</b>8-Cl-A long circulation liposomes could prolong the action-time of 8-Cl-A in vivo.</p>