Preparation, identification and inclusion actions of irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex / 药学学报
Acta Pharmaceutica Sinica
; (12): 369-372, 2005.
Article
em Zh
| WPRIM
| ID: wpr-353493
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To perpare and identify irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex (irisquinone-HP-beta-CD), as well as to study the inclusion mechanism and molecule stoichiometry between irisquinone and hydroxypropyl-beta-cyclodextrin.</p><p><b>METHODS</b>Irisquinone-HP-beta-CD was prepared by freeze-drying technique. The ratio of host and guest was also studied in inclusion process by mol gradient and continuing variational methods. At the same time, the inclusion complex was identified by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).</p><p><b>RESULTS</b>It was demonstrated that the solubility of irisquinone was enhanced markedly by inclusion with HP-beta-CD when stoichiometry was 2:1 of host and guest at 25 degrees C, 35 degrees C and 45 degrees C.</p><p><b>CONCLUSION</b>The solubility and stability of irisquinone could be increased by preparing the inclusion complex with hydroxypropyl-beta-cyclodextrin.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Solubilidade
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Difração de Raios X
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Varredura Diferencial de Calorimetria
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Química
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Benzoquinonas
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Beta-Ciclodextrinas
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Composição de Medicamentos
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Estabilidade de Medicamentos
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2-Hidroxipropil-beta-Ciclodextrina
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Liofilização
Tipo de estudo:
Diagnostic_studies
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Article