Distribution and pharmacokinetics of 20S-ginsenoside Rg3 eyeointment in rabbit eye / 药学学报
Acta Pharmaceutica Sinica
;
(12): 258-261, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-353516
ABSTRACT
<p><b>AIM</b>To determine 20S-ginsenoside Rg3 in various tissues of rabbit eye and evaluate pharmacokinetics following its topical application.</p><p><b>METHODS</b>45 rabbits were divided into 9 groups. Aqueous humor, cornea and iris-ciliary body were collected at 0.017, 0.033, 0.083, 0.167, 0.5, 1.0, 1.5, 2.0 and 3.0 h following topically applying 1% 20S-ginsenoside Rg3 eyeointment and the concentrations in eye tissues were measured by HPLC.</p><p><b>RESULTS</b>The pharmacokinetics of 20S-ginsenoside Rg3 in rabbit eye were described by one-compartment model. The peak times in aqueous humor, cornea and iris-ciliary body were 0.42, 0.16 and 0.19 h, and T(1/2) were 0.1, 0.9 and 0.8 h respectively.</p><p><b>CONCLUSION</b>The method of determining 20S-ginsenoside Rg3 in rabbit eyes was established. The pharmacokinetics parameters were determined.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pomadas
/
Humor Aquoso
/
Sangue
/
Farmacocinética
/
Distribuição Tecidual
/
Iris
/
Corpo Ciliar
/
Administração Tópica
/
Cromatografia Líquida de Alta Pressão
/
Área Sob a Curva
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Artigo
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