Clinicopathological features of primary splenic histiocytic sarcoma: a case report and literature review / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinicopathological features of primary splenic histiocytic sarcoma.</p><p><b>METHODS</b>Clinicopathological characterstics were analyzed in a case of primary splenic histiocytic sarcoma and related literatures were reviewed.</p><p><b>RESULTS</b>A 69-year old woman had unexplained debility and palpitation after exertion for a month. CT showed splenomegaly with multiple occupancy. The resected spleen measured 28 cm × 18 cm × 10 cm. Histopathological examination demonstrated that the neoplastic cells diffusely infiltrated splenic sinus. The neoplastic cells were characterized by well-defined cell contour, large pleomorphic nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. Tumor cells with cytoplasmic vacuoles and intense hemophagocytosis were observed. These cells strongly expressed histiocytic markers CD68 and CD163. Immunostaining for LCA, Vim was positive, but negative for CD1a, S-100, CD30, CK, CD20, CD3, CD21.</p><p><b>CONCLUSIONS</b>Immunohistochemistry plays a key role in the diagnosis of primary splenic histiocytic sarcoma.</p>