Treatment outcomes of 125 children with aplastic anemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 531-535, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-353596
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the outcome of childhood aplastic anemia received allogenic hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST).</p><p><b>METHODS</b>The clinical data of 125 consecutive children with aplastic anemia (AA) in our hospital were retrospectively analyzed.</p><p><b>RESULTS</b>According to the clinical manifestations, the 125 AA children were divided into two groups SAA (n = 79) and NSAA (n = 46). There was no significant difference between the two groups in sex, age and follow-up duration (P > 0.05). The median follow-up was 25 (6 - 89) months. 103 cases received IST and 22 received allogenic HSCT. In SAA group, the response rate was better in patients received allogenic HSCT (n = 21) than in those received IST (n = 58) (85.7% vs 53.4%, P < 0.01). SAA patients received IST were further divided into two groups 47 received antithymocyte globulin (ATG) and cyclosporine-A (CsA) combined therapy, 11 received CsA alone. There was no significant difference in total response rates (55.3% vs 45.5%, P = 0.555) and cure rates (42.6% vs 27.3%, P = 0.499) between the two groups. In NSAA group, 45 patients received IST and 1 received allogenic HSCT. In the IST treated NSAA patients, there was also no statistic significance in cure rates (36.4% vs 32.4%, P = 0.806) and total effective rates (63.6% vs 64.7%, P = 0.949) between ATG and CsA combined therapy (n = 11) and CsA alone therapy (n = 34).</p><p><b>CONCLUSION</b>The outcome of children with AA received allogenic HSCT was obviously better than those received IST. IST is still the choice for patients without suitable donors for HSCT.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Resultado do Tratamento
/
Ciclosporina
/
Usos Terapêuticos
/
Imunossupressores
/
Anemia Aplástica
/
Soro Antilinfocitário
Limite:
Criança
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2010
Tipo de documento:
Artigo
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