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Relationship between endothelial protein C receptor gene 6936A/G polymorphisms and deep venous thrombosis / 中华血液学杂志
Chinese Journal of Hematology ; (12): 607-609, 2010.
Artigo em Chinês | WPRIM | ID: wpr-353607
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between endothelial protein C receptor(EPCR) gene 6936A/G polymorphism and deep vein thrombosis (DVT).</p><p><b>METHODS</b>The study group included 65 DVT patients and 71 normal controls. Plasma sEPCR was measured by ELISA. Genomic DNA was extracted by using Genomic Purification Kit. A 315bp EPCR product was amplified by a standard PCR reaction, and the bands were confirmed by direct sequencing after purification.</p><p><b>RESULTS</b>(1) sEPCR levels in healthy controls with 6936AG genotype were significantly higher than that in those with 6936AA genotype \[(0.97 ± 0.32) ng/L vs (0.61 ± 0.24) ng/L, P < 0.01)\], and so did in DVT patients \[(0.87 ± 0.21) ng/L vs (0.50 ± 0.18) ng/L, P < 0.01\]. (2) The sEPCR levels of DVT patients \[(0.68 ± 0.32) ng/L\] were significantly higher than that of healthy controls \[(0.54 ± 0.22) ng/L\](P < 0.05). (3) The distribution of 6936A/G genotype was higher in DVT patients than in healthy controls (P < 0.05). (4) Subjects with 6936A/G had an increased risk of thrombosis (OR = 2.75, 95%CI = 1.04 - 7.30) (P < 0.05).</p><p><b>CONCLUSIONS</b>EPCR gene 6936A/G polymorphism is associated with increased plasma sEPCR levels. The sEPCR levels in DVT patients were significantly higher than that in healthy controls. The subject with 6936AG likely had an increased risk of thrombosis.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Trombose / Proteína C / Estudos de Casos e Controles / Trombose Venosa / Genética / Metabolismo Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Trombose / Proteína C / Estudos de Casos e Controles / Trombose Venosa / Genética / Metabolismo Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2010 Tipo de documento: Artigo