Post-transcriptional protein modification of Gata4 / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 800-803, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-353861
ABSTRACT
Gata4 is an important transcription factor in heart development. Gata4 post-transcriptional protein modification regulates transcriptional activity and DNA binding, which in turn affects expression of downstream genes and transcription factors, differentiation of embryonic stem cells and cardiogenesis. This article summarizes the effect of post-transcriptional protein modification on transcriptional activity of Gata4 and the relationship between this effect and congenital heart disease. It was shown that acetylation, phosphorylation and SUMOylation upregulate transcriptional activity, DNA binding, downstream gene expression and embryonic stem cell differentiation. On the other hand, methylation and deacetylation downregulate Gata4 transcriptional activity. Post-transcriptional protein modification of Gata4 is very important in clinical research on congenital and other heart diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Acetilação
/
Química
/
Processamento de Proteína Pós-Traducional
/
Fator de Transcrição GATA4
/
Sumoilação
/
Genética
/
Metabolismo
/
Metilação
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2012
Tipo de documento:
Artigo
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