Study on pharmacokinetics of ferulic acid loaded liposome-in-chitosan-microspheres in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1751-1754, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-354130
ABSTRACT
In this paper, the pharmacokinetics of ferulic acid loaded liposome-in-chitosan-microspheres was investigated. Eighteen Sprague-Dawley rats were divided into 3 groups randomly. Each group was administered orally of ferulic acid, ferulic acid loaded chitosan microspheres and ferulic acid loaded liposome-in-chitosan-microspheres, respectively. Then blood samples were obtained from fossa orbitalis at different time points. The concentration of ferulic acid in blood was analyzed by a HPLC method using coumarin as internal standard. The data were analyzed by DAS program. The t(max), MRT and t(1/2beta) of liposome-in-chitosan-microspheres were 2.500, 7.487 and 7.818 h, respectively, which were much longer than crude drug and chitosan microspheres. This results demonstrated that liposome-in-chitosan-microspheres had better sus-tained-releasing property. The AUC of liposome-in-chitosan-microspheres was 6.08 times higher than crude drug and 1.21 times higher than chitosan microspheres, which verified that liposome-in-chitosan-microspheres could enhance oral absorption.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Órbita
/
Fatores de Tempo
/
Materiais Biocompatíveis
/
Sangue
/
Farmacocinética
/
Distribuição Aleatória
/
Administração Oral
/
Ratos Sprague-Dawley
/
Ácidos Cumáricos
/
Preparações de Ação Retardada
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo
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