Influence of penetration enhancers on in vitro transdermal permeation of L-tethrahydropalmatine / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1729-1732, 2011.
Article
em Zh
| WPRIM
| ID: wpr-354134
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of different penetration enhancers on the in vitro transdermal permeation of 1-tethrahydropalmatine (L-THP) through rat skin.</p><p><b>METHOD</b>Both natural and chemical synthesis penetration enhancers were applied singly or jointly to investigate the skin permeation rates of l-THP. The skin permeation profiles were evaluated by Valian-Chien permeation cells with isolated rat skin. HPLC-UV method was established to determine the concentration of l-THP in samples.</p><p><b>RESULT</b>As chemical synthesis penetration enhancer was used alone, 8% azone was observed to be the optimal penetration enhancer with the maximal penetration rate of 21.153 microg x cm(-20 x h(-1). Although 2% menthol crystal or 5% eucalyptus oil was effective as a natural penetration enhancer when used alone, the average penetration rate reached only half of that of 8% azone. The penetration potency of either menthol oil or menthol crystal combined with 8% azone was more effective than that of azone alone (P < 0.05).</p><p><b>CONCLUSION</b>Either menthol oil or menthol crystal combined with 8% azone is effective on transdermal penetration of l-THP in vitro. There is significant synergistic effect when natural penetration enhancers combined with chemical synthesis penetration enhancers.</p>
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Índice:
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Assunto principal:
Permeabilidade
/
Farmacologia
/
Pele
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Absorção Cutânea
/
Azepinas
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Alcaloides de Berberina
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Administração Cutânea
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Óleos Voláteis
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Farmacocinética
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Química
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Article