Study on anaphylaxis and hemocytolysis of 6 kinds of tween-80 injection from different souce / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the anaphylaxis and hemocytolysis of 6 kinds of tween-80 injection from different source.</p><p><b>METHOD</b>The Hartley albinism guinea pig was used to carry on the active systematic anaphylaxis (ASA) and the passive cutaneous anaphylaxis (PCA). The in vitro hemolytic experiment and the hemocytolysis was observed by means of spectrophotometry on the domestic rabbit.</p><p><b>RESULT</b>The result of ASA and PLA of 6 kinds of tween-80 injection from different source assumed the negative. In observation time, the temolysis rate of 3 kinds of tween-80 injection are more than 5%, while the others are also more than 5% only in the highly concentrated test tube.</p><p><b>CONCLUSION</b>Six kinds of tween-80 injection from different source have not caused the immune-mediated anaphylaxis, but it may have hematolysis tendency on intravenous injection. The hemocytolysis of tween-80 may not be entirely caused by the impurities. It is worthy of further study that the physical and chemical properties of the product itself and the undeserved concentration is doubtful whether there is also some internal relations with the generation of hemolytic.</p>