In vitro comparison of transdermal characteristics of xiaoyu ointment and xiaoyu plaster / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1599-1602, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-354196
ABSTRACT
<p><b>OBJECTIVE</b>Through the comparison of Xiaoyu ointment and xiaoyu plaster by in vitro transdermal demonstrate, to demonstrate the scientificity and feasibility of reformed formulation.</p><p><b>METHOD</b>The improved Franz diffusion cells and in vitro rabbit skin were used in vitro penetration experiment with emodin as an indicator of penetration rate quantitated by HPLC.</p><p><b>RESULT</b>The cumulative penetration rate of emodin in Xiaoyu ointment fit the model of Weibull distribution, while the cumulative penetration rate of emodin in Xiaoyu plaster fit the model of Density equation. Take emodin as an index,the transdermal rate in Xiaoyu plaster was 1.93 times as Xiaoyu ointment, and the total penetrated amount was 2.84 times as Xiaoyu ointment. The results showed that the emodin of xiaoyu plaster reserved in the skin were 3.95 times more than the ointment.</p><p><b>CONCLUSION</b>The penetration rate, total penetrated amount and the reserves in the skin of Xiaoyu plaster were better than the ointment, and the transdermal dosage form was better than the original form.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pomadas
/
Pele
/
Absorção Cutânea
/
Administração Cutânea
/
Farmacocinética
/
Cromatografia Líquida de Alta Pressão
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS