Structure charateristics of mitoxantrone transforsomes / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 555-559, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-354251
ABSTRACT
This study sought to clarify the molecular location and the interaction between mitoxantrone and mitoxantrone transforsomes. The anthraquinone of mitoxantrone, a heterocyclic ring that intercalates in the lipid of bilayer, was determined by UV-spectrophotometry and electron probes scan microscopy. Two aminoethylamino side-chains of the drugs fit to the phosphates of lecithin were determined by 8-value, thus the interaction with lecithin was substantiated. Differential scanning calorimetry confirmed that mitoxantrone has remarkable stabilizing effect on the mitoxantrone transforsomes membrane. The mitoxantrone binds tightly to lecithin. So a high degree of encapsulation efficiency and the sustained-release character of mitoxantrone transforsomes are verified.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espectrofotometria
/
Varredura Diferencial de Calorimetria
/
Química
/
Antraquinonas
/
Mitoxantrona
/
Preparações de Ação Retardada
/
Lecitinas
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2005
Tipo de documento:
Artigo
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