Genotoxicity comparison between gasoline- and methanol-fueled exhaust by TK gene mutation assay / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 347-350, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-354302
ABSTRACT
Methanol fuel is a most promising substitute for gasoline. It is scarcely reported about methanol-fueled exhaust on the health effect, neither about genotoxicity research between methanol- and gasoline-fueled exhaust. In the present study, the two kinds of exhaust were sampled directly from tailpipe at the same type bus, the same state, L5178Y thymidine kinase (TK) gene mutation assay was used to investigate their genotoxicity at the same dose range, and compared with micronucleus and comet assay. The results showed that the genotoxicity of gasoline-fueled exhaust is stronger than that of methanol-fueled exhaust, while the cytotoxicity of methanol-fueled exhaust is stronger than that of gasoline-fueled exhaust at dose range. The study demonstrated that L5178Y TK gene mutation assay is more sensitive than micronucleus and comet assay.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Timidina Quinase
/
Emissões de Veículos
/
Gasolina
/
Veículos Automotores
/
Metanol
/
Genética
/
Testes de Mutagenicidade
/
Mutação
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS