The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 420-421, 2006.
Article
em Zh
| WPRIM
| ID: wpr-354355
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of MMP-2, MT1-MMP and TIMP-2 in the carcinogenesis of oral lichen planus (OLP).</p><p><b>METHODS</b>Immunohistochemistry was performed to examine the expression of OLP and compare with that of NOM.</p><p><b>RESULTS</b>The expression of these proteinases significantly increased from NOM, non-atrophic OLP, to atrophic OLP and OSCC. The expression of MMP-2 and MT1-MMP in atrophic OLP was significantly higher than in non-atrophic OLP. Furthermore, the expression of TIMP-2 consequently increased with the increasing of the MMP, but the increase of TIMP-2 was less than that of MMP.</p><p><b>CONCLUSIONS</b>MMP may be useful marker to judge the possibility of malignant change of OLP.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Patologia
/
Neoplasias Bucais
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Imuno-Histoquímica
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Carcinoma de Células Escamosas
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Líquen Plano Bucal
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Inibidor Tecidual de Metaloproteinase-2
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Metaloproteinase 2 da Matriz
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Metaloproteinase 14 da Matriz
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Metabolismo
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Mucosa Bucal
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2006
Tipo de documento:
Article