Your browser doesn't support javascript.
loading
Interleukin-18 promoter gene -607C/A polymorphism and tuberculosis risk: a meta-analysis / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 3360-3363, 2013.
Artigo em Inglês | WPRIM | ID: wpr-354480
ABSTRACT
<p><b>BACKGROUND</b>Numerous studies have evaluated the association between interleukin-18 (IL-18) promoter gene -607C/ A (rs1946518) polymorphism and tuberculosis (TB) risk. However, the results remain apparently conflicting. The aim of this study was to investigate whether IL-18-607C/A polymorphism is associated with susceptibility to TB.</p><p><b>METHODS</b>Publications addressing the association between the IL-18-607C/A polymorphism and TB risk were selected from the Pubmed, Cochrane Library, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.0.25 and STATA 11.0 software.</p><p><b>RESULTS</b>Eight case-control studies with a total of 1166 TB patients and 1734 controls were retrieved. Meta-analysis results showed significant association between IL-18-607C/A polymorphism and TB risk in all comparisons of the A allele versus C allele (OR=1.17, 95% CI 1.05-1.30, P=0.004), AA versus CC (OR=1.43, 95% CI 1.14-1.81, P=0.002), CA+AA versus CC (OR=1.20, 95% CI 1.01-1.42, P=0.04) and AA versus CA+CC (OR=1.30, 95% CI 1.07-1.58, P=0.007). In subgroup analysis by nationality, a significant association between IL-18-607C/A polymorphism and TB risk in the comparisons of A versus C, CA+AA versus CC and AA versus CA+CC (OR=1.22, 95% CI 1.07-1.38, P=0.002; OR=1.31, 95% CI 1.06-1.61, P=0.01; OR=1.32, 95% CI 1.07-1.63, P=0.01, respectively) were found in Chinese population but not in Indian and Iranian populations.</p><p><b>CONCLUSION</b>This study suggests that the -607C/A polymorphism of IL-18 gene would be a risk factor for TB, especially in Chinese population. To further evaluate gene-to-gene and gene-to-environment interactions on -607C/A polymorphism and tuberculosis risk, more studies with thousands of patients are required.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tuberculose / Epidemiologia / Regiões Promotoras Genéticas / Predisposição Genética para Doença / Interleucina-18 / Genética Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco / Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2013 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tuberculose / Epidemiologia / Regiões Promotoras Genéticas / Predisposição Genética para Doença / Interleucina-18 / Genética Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco / Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2013 Tipo de documento: Artigo