Design, synthesis and antidepressive activity of duloxetine derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 869-873, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-354562
ABSTRACT
In this paper, duloxetine was chosen as the lead compound. The pharmacophores with 5-HT(1A) antagonism activity were used to replace the naphthyl of duloxetine. A series of duloxetine derivatives had been designed and synthesized and whose structures were confirmed with elemental analysis, MS and H NMR. All synthesized compounds were tested by tail suspension test and forced swimming test in vivo. The test results revealed that most of the compounds have shown better activity than duloxetine at the same dosage. Some of them are worth to be studied further.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Natação
/
Tiofenos
/
Estrutura Molecular
/
Química
/
Elevação dos Membros Posteriores
/
Antagonistas do Receptor 5-HT1 de Serotonina
/
Cloridrato de Duloxetina
/
Camundongos Endogâmicos ICR
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo
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