Expressions and significance of B7-H1 and programmed death-1 in lymphocytes from patients with chronic hepatitis B virus infection / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 738-741, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-354645
ABSTRACT
<p><b>OBJECTIVE</b>To examine the expressions of B7-H1 and its receptor programmed death-1 (PD-1) on circulating T cells and myeloid dendritic cells (mDCs) in patients with chronic hepatitis B virus (HBV) infection and to investigate the correlation between their expressions and their disease status.</p><p><b>METHODS</b>The expressions of B7-H1 and PD-1 on mDCs and T lymphocytes in 30 patients with chronic HBV infection and 28 healthy controls were analyzed by a fluorescence-activated cell sorter (FACS). Real time-polymerase chain reaction (RT-PCR) was used to measure the serum HBV DNA load.</p><p><b>RESULTS</b>Both B7-H1 and PD-1 were significantly upregulated on T cells and mDCs in those patients. Their expressions were positively correlated with the patients serum ALT levels and HBV DNA loads.</p><p><b>CONCLUSION</b>B7-H1 and PD-1 expressions in our patients with chronic hepatitis B are closely associated with their disease status.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Dendríticas
/
Linfócitos T
/
Antígenos CD
/
Estudos de Casos e Controles
/
Hepatite B Crônica
/
Antígeno B7-H1
/
Metabolismo
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS