Impacts of HIV-1 resistance mutations associated with nucleoside reverse transcriptase inhibitors on viral fitness / 病毒学报
Chinese Journal of Virology
; (6): 291-296, 2012.
Article
em Zh
| WPRIM
| ID: wpr-354733
Biblioteca responsável:
WPRO
ABSTRACT
Nucleoside reverse transcriptase inhibitors which act as a major component of highly active antiretroviral therapy regimens are widely used in treatment of Acquired Immune Deficiency Syndrome. However, the emergence of drug-resistant variants of HIV-1 severely limits the effectiveness of these drugs. Many drug resistance mutations confer a fitness cost, which can be partially overcome by compensatory mutations or other molecular mechanisms. This review focuses on the impacts of resistance mutations emerging during treatment with nucleoside reverse transcriptase inhibitors on viral fitness, and inter actions between these mutations.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Fisiologia
/
Virologia
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Infecções por HIV
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HIV-1
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Inibidores da Transcriptase Reversa
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Farmacorresistência Viral
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Usos Terapêuticos
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Tratamento Farmacológico
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Transcriptase Reversa do HIV
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Genética
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Virology
Ano de publicação:
2012
Tipo de documento:
Article