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Semen-derived enhancer of viral infection--a key factor in sexual transmission of HIV / 病毒学报
Chinese Journal of Virology ; (6): 84-88, 2012.
Artigo em Chinês | WPRIM | ID: wpr-354766
ABSTRACT
Semen-derived enhancer of viral infection(SEVI) is a peptide fragment (PAP248-286) from prostatic acid phosphatase(PAP), which can enhance human immunodeficiency virus infection. The mechanisms of SEVI include (1) SEVI with several cationic amino acid residues reduced electrostatic repulsion between HIV virus and the target cells; (2) The disorder state of SEVI in the human body fluids was helpful to the interaction between virus and the target cell membranes; (3) SEVI could capture HIV particles directly and speed the velocity of virus on the surface of the target cells and improve adsorption and fusion. Currently, the substances of inhibiting SEVI activity include EGCG from green tea, small molecule compound of aminoquinoline Surfen, ThT analogs BTA-EG6. Those compounds might block the combination of HIV and SEVI or prevent the formation of amyloid fibers, and then reduce the enhancement of SEVI. The studies on the biological characteristics and mechanisms of SEVI have a big benefit for the prevention and treatment of HIV infection.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Sêmen / Doenças Virais Sexualmente Transmissíveis / Infecções por HIV / Eletricidade Estática Limite: Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Virology Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Sêmen / Doenças Virais Sexualmente Transmissíveis / Infecções por HIV / Eletricidade Estática Limite: Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Virology Ano de publicação: 2012 Tipo de documento: Artigo