Clinical and laboratory studies on childhood acute leukemia with 11q23 abnormalities / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 358-361, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-354861
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the interrelations among morphology, immunology, cytogenetics and clinical outcome in childhood acute leukemia with 11q23 abnormalities.</p><p><b>METHODS</b>Eighteen patients with 11q23 abnormalities, from 320 childhood acute leukemia patients, were retrospectively analysed for cell morphology, flow cytometry, immunophenotyping, R-banding karyotype as well as clinical features and prognosis. Twenty cases of childhood AL with normal karyotype during the same period were used as control.</p><p><b>RESULTS</b>The incidence of 11q23 abnormalities in our childhood acute leukemia patients was 5.63% including 14 acute lymphoblastic leukemia (ALL) and 4 acute myeloid leukemia (AML). Of 16 cases immunophenotypically tested, 13 expressed lymphoid antigens and 3 CD(34) and other myeloid antigens. Karyotype analysis disclosed the following abnormalities t(4; 11)(q21; q23) in 6 cases, t(10; 11)(p13; q23) in 3, t(11; 19)(q23; p13) in one and del(11)(q23) in 6. The complete remission rate for these patients with 11q23 abnormalities was comparable to that of the control (72.2% vs 80.0%, P > 0.05), while the mortality rate in the former was significantly higher than that in the latter (61.1% vs 25.0%, P < 0.05).</p><p><b>CONCLUSIONS</b>11q23 abnormalities were mainly seen in childhood ALL and acute monocytic leukemia with unique prognostic features.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Cromossomos Humanos Par 11
/
Leucemia
/
Doença Aguda
/
Estudos Retrospectivos
/
Imunofenotipagem
/
Aberrações Cromossômicas
/
Análise Citogenética
/
Tratamento Farmacológico
/
Alergia e Imunologia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2003
Tipo de documento:
Artigo
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