Hypermethylation status of blu gene in nasopharyngeal lymphoma / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 138-140, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-354901
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the hypermethylation status of blu gene promoter in nasopharyngeal NK/T cell lymphoma and its role in the tumorigenesis and molecular diagnosis of this lymphoma.</p><p><b>METHODS</b>Twenty cases of paraffin-embedded nasopharyngeal NK/T cell lymphomas tissues were studied by using methylation specific PCR (MSP).</p><p><b>RESULTS</b>Hypermethylation of blu gene promoter is detected in 6 of 20 (30%) nasopharyngeal NK/T cell lymphoma. The 6 positive cases were 4 in 15 nasopharyngeal NK cell lymphomas, 1 of 2 NK like T cell lymphoma and 1 in 3 peripheral T cell lymphomas (unspecified type).</p><p><b>CONCLUSION</b>Hypermethylation of blu gene promoter in nasopharyngeal NK/T cell lymphoma indicated the inactivation of blu gene and its possible role in the tumorigenesis of this lymphoma. blu gene methylation could be detected in paraffin-embedded tissue and used as a new molecular marker for the diagnosis of this lymphoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias Nasofaríngeas
/
Reação em Cadeia da Polimerase
/
Genes Supressores de Tumor
/
Metilação de DNA
/
Proteínas Supressoras de Tumor
/
Genética
/
Linfoma
/
Métodos
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2003
Tipo de documento:
Artigo
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