Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the expression of interleukin 18 (IL-18) and prostaglandin E2 (PGE2) and their relationship in the synoviocytes of patients with osteoarthritis (OA).</p><p><b>METHODS</b>The synovial tissues were obtained from 30 OA patients to isolate the synoviocytes for primary culture. The concentrations of IL-18 and PGE2 in the supernatants of synoviocyte culture were measured by enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The concentration of IL-18 averaged 51.559-/+27.614 pg/ml and PGE2 327.036-/+333.561 pg/ml in the supernatant of the synoviocytes. A significant positive correlation was noted between their expressions (r=0.863, P<0.01).</p><p><b>CONCLUSION</b>IL-18 may induce the production of PGE2, and their interactions they may play an important role in the pathogenesis of OA.</p>