Therapeutic effect of infliximab on moderate and severe active rheumatoid arthritis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 724-726, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-355034
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical efficacy of infliximab in the treatment of moderate and severe active rheumatoid arthritis (RA).</p><p><b>METHODS</b>This randomized double-blind II/III clinical trial involved 30 patients with moderate and severe active RA, who were randomly allocated into 3 groups (groups A, B, and C) at the ratio of 311. At weeks 0, 2, 6, and 14, the patients in groups A and C received infliximab or placebo, and those in group B had placebo at week 14 with a stable background dose of methotrexate. The indicators for efficacy evaluation included the proportions of ACR20/50/70 of the responders and DAS28. The sharp scores of the hand joints were recorded before and after the treatment.</p><p><b>RESULTS</b>Twenty-nine patients completed the clinical trial (18 in group A, 5 in group B, and 6 in group C). At week 14, the proportions of ACR20/50/70 in the 3 groups reached 83.33%, 60%, and 33.33%, respectively (P<0.05), as compared to 100%, 100%, and 33.33% at week 18 (P<0.05). The other indicators for clinical efficacy evaluation also suggested similar clinical improvement of the patients (P=0.000). The proportions of the patients with DAS28<3.2 and DAS28<2.6 were significantly different. Compared to the baseline, the Sharp scores in group A showed no significant changes at week 18 (P>0.930), while those in group C exhibited significant radiographic progression (P<0.044).</p><p><b>CONCLUSION</b>Infliximab produces good short-term therapeutic effect against moderate and severe active RA and may help arrest the radiographic progression of the diseases, which can be more obvious in patients with moderate severity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite Reumatoide
/
Terapêutica
/
Diagnóstico por Imagem
/
Radiografia
/
Método Duplo-Cego
/
Fator de Necrose Tumoral alfa
/
Usos Terapêuticos
/
Alergia e Imunologia
/
Infliximab
/
Anticorpos Monoclonais
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo diagnóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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