Neuronal differentiation of PC12 cells induced by human periodontal ligament fibroblast-conditioned medium / 南方医科大学学报
Journal of Southern Medical University
;
(12): 549-551, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-355075
ABSTRACT
<p><b>OBJECTIVE</b>To examine whether human periodontal ligament fibroblasts (hPDLF) express neural growth factor (NGF).</p><p><b>METHODS</b>PC12 cells were cultured in hPDLF-conditioned medium to evaluate the secretion of NGF by hPDLF.</p><p><b>RESULTS</b>hPDLF-conditioned medium resulted in neuronal differentiation and neurite outgrowth from PC12 cells. Only a small percentage of the cells grown in anti-NGF antiserum and DMEM expressed neuritis.</p><p><b>CONCLUSION</b>hPDLF are capable of synthesizing NGF and secreting it into the medium as the signaling molecules for innervation during the healing of the periodontal tissue.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Ligamento Periodontal
/
Farmacologia
/
Feocromocitoma
/
Periodonto
/
Diferenciação Celular
/
Células Cultivadas
/
Células PC12
/
Meios de Cultivo Condicionados
/
Biologia Celular
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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