Bilateral Metachronous Breast Cancer in Neurofibromatosis Type 1
Journal of the Korean Surgical Society
;
: 388-391, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-35508
ABSTRACT
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease, characterized by cafe-au-lait spot, axillary and inguinal freckle, peripheral neurofibroma and pigmented iris hamartoma. The various cancer incidences are increased in the NF1. But NF1 with breast cancer is rare. In this report we present a case of a 46-year-old NF1 female with a bilateral metachronous breast cancer. The patient has no BRCA2 mutation, but there are two unclassified variants in the exon 11 of BRCA1. The possibility of LOH of BRCA1 gene in the cancer tissue cannot be excluded.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mama
/
Neoplasias da Mama
/
Iris
/
Éxons
/
Incidência
/
Neurofibromatose 1
/
Neurofibromatoses
/
Manchas Café com Leite
/
Genes BRCA1
/
Hamartoma
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
2009
Tipo de documento:
Artigo
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