Progesterone promotes the proliferation and migration of cultured breast cancer cells / 南方医科大学学报
Journal of Southern Medical University
;
(12): 443-446, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-355105
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of progesterone on the growth and migration of breast cancer cells.</p><p><b>METHODS</b>MCF-7 and T-47D cells were cultured in DMEM and stimulated with 100 nmol/L progesterone for 48 h, and the cell proliferation was evaluated by MTT assay, cell migration by wound-healing assay and E-catherin expression by Western blotting.</p><p><b>RESULTS</b>Progesterone stimulated the cell proliferation and migration and down-regulated the expression of E-catherin in both MCF-7 and T-47D cells.</p><p><b>CONCLUSIONS</b>Progesterone stimulates the cell proliferation and migration of cultured breast cancer cells, suggesting the clinical significance of anti-progesterone therapy in breast cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Progesterona
/
Neoplasias da Mama
/
Células Tumorais Cultivadas
/
Caderinas
/
Movimento Celular
/
Proliferação de Células
/
Metabolismo
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS