Characteristics of polymorphism of 129th amino acid in PRNP among Han and Uighur Chinese / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 105-108, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-355117
ABSTRACT
<p><b>BACKGROUND</b>An amino acid polymorphism for Met to Val has been identified at PrP codon 129 from different human races. In this study,the characteristics of polymorphism of PRNP 129th amino acid in Han and Uighur Chinese have been investigated.</p><p><b>METHODS</b>Human DNAs were extracted from peripheral lymphocytes and PrP gene fragments were amplified with a specific PCR protocol. The distribution of 129th amino acid in PRNP was determined by a PCR-RFLP and the results were analyzed with software SAS for Windows 6.12.</p><p><b>RESULTS</b>The frequencies of the allele 129 Met and 129 Val were 97.0% and 3.0% in Han Chinese, whereas 91.4% and 8.6% in Uighur Chinese. The frequency of 129 M/M phenotypes in Han Chinese was significantly higher than that in Uighur Chinese (P=0.0490). Comparing the phenotype distributions of codon 129 of Han Chinese with that of Japanese and Caucasian, there was significant difference with Caucasian (P=0.0005),but there was no difference with Japanese (P=0.5040).</p><p><b>CONCLUSIONS</b>The polymorphism of 129th amino acid in PRNP of Han Chinese is similar to Japanese, but different from Uighur Chinese.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Príons
/
Códon
/
China
/
Doenças Priônicas
/
Povo Asiático
/
População Branca
/
Frequência do Gene
/
Genética
/
Genótipo
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2002
Tipo de documento:
Artigo
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