Expression of P53 and Bax in rat liver induced by microcystin LR in vivo / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To examine the expression of P53, Bcl-2 and Bax proteins in rat liver after exposed to microcystin LR.</p><p><b>METHODS</b>SD rats received microsystin LR by gastric perfusion. The expression of P53, Bax and Bcl-2 in liver was detected by Western blot.</p><p><b>RESULTS</b>The expression of P53 and Bax in each treatment group increased significantly compared with that in control group(P<0.05), with the exception of 0.1 microg/kg LR exposure group. Moreover, with exposure levels increasing the expression of P53 and Bax increased gradually; while no changes of the expression of Bcl-2 were observed.</p><p><b>CONCLUSION</b>P53 and Bax may play important roles in microcystin LR induced apoptosis, but Bcl-2 seems not be involved in this process.</p>