High central pulse pressure level is associated with cardiovascular disease in patients receiving maintenance peritoneal dialysis / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the association between central pulse pressure level and cardiovascular diseases (CVD) in patients receiving maintenance peritoneal dialysis.</p><p><b>METHODS</b>This cross-sectional study was conducted in 234 patients on maintenance peritoneal dialysis. Central pulse pressure levels were measured using a SphygmoCor analyzer, and cardiovascular diseases were defined as diagnosed ischemic heart disease, heart failure, stroke or peripheral vascular disease.</p><p><b>RESULTS</b>The central pulse pressure levels of patients with CVD were significantly higher than those without CVD (51.7 ± 22.5 vs 43.7 ± 17.8 mmHg, P=0.004), while the brachial pulse pressure levels were comparable between the two patient groups. After adjusting for brachial pulse pressure and other relevant risk factors, central pulse pressure level was found to independently associate with CVD (adjusted OR=1.33, 95% CI 1.01-1.73, P=0.04 ).</p><p><b>CONCLUSION</b>High central pulse pressure level may serve as a risk factor for CVD in patients on maintenance peritoneal dialysis.</p>