Expression of helicase DDX41 in human dental pulp tissues and cells / 南方医科大学学报
Journal of Southern Medical University
;
(12): 587-590, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-355322
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of D-E-A-D-box polypeptide 41 (DDX41) in human dental pulp tissues and cells.</p><p><b>METHODS</b>The mRNA and protein expressions of DDX41 in human dental pulp cells were detected by RT-PCR and immunocytochemistry, and the expression of DDX41 in human dental pulp tissues was investigated by immunohistochemistry.</p><p><b>RESULTS</b>Strong expressions of DDX41 mRNA and protein were detected in dental pulp cells. In dental pulp tissues, DDX41 was expressed in the cytoplasm and nucleus of odontoblasts.</p><p><b>CONCLUSION</b>DDX41/STING-dependent TBK1-IRF3-IFN-β signaling pathway may play a role in innate immune responses of the dental pulp to caries and pulpitis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Imuno-Histoquímica
/
Transdução de Sinais
/
Núcleo Celular
/
Células Cultivadas
/
Citoplasma
/
Polpa Dentária
/
RNA Helicases DEAD-box
/
Metabolismo
/
Odontoblastos
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2015
Tipo de documento:
Artigo
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